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教师名录

欧宝在线登录:杨云云

作者:欧宝在线登录发布时间:2022年05月16日 17:03

31eda601b30a7440159e4a5ca9855c0

一、基本信息

杨云云,博士,副教授,硕士生导师

电子邮件:yang_yy(at)hubu.edu.cn

研究方向:主要结合结构生物学、生物化学等手段研究:(1)重要工业酶的结构和催化机制;(2)疾病相关重要蛋白质的结构和分子机制;(3)生成抗肿瘤天然产物过程中的酶促反应机制。已在Cell、Immunity、Angew Chem Int Ed、ACS CatalysisSCI期刊发表15篇高水平文章,其中以第一作者(包含共同第一)在Immunity、Angew Chem Int Ed、ACS Catalysis(两篇)等高水平SCI期刊上发表文章6篇,2篇获选为封面文章,申请国内外专利4项。

二、教育背景

20162019  清华大学,博士

20122015  天津科技大学和中科院天津工生所,联合培养硕士

20082012  青岛农业大学海都学院,学士

三、工作经历

2021至今    欧宝在线登录,副教授

20202021  欧宝在线登录,博士后

20152016  清华大学,科研助理

四、主持科研项目

1. 国家重点专项青年项目,2021.12?2026.11,100万,项目骨干

2. 国家自然科学基金青年项目,2022.01?2024.01,30万,主持

3. 湖北省人才项目,30万,主持

4. 中国博士后特别资助,2021.03?2022.01,18万,主持

5. 中国博士后面上项目,2020.04?2022.01,8万,主持

6. 湖北省博士后创新研究岗位,2020.04?2022.01,6万,主持

五、代表性论文#共同一作,*通讯作者)

1. Yang, Y.#, Li, L.#, Yuan, L.#, Zhou, X.#, Duan, J., Xiao, H., Cai, N., Han, S., Ma, X., Liu, W., Chen, C. C., Wang, L., Li, X., Chen, J., Kang, N., Chen, J., Shen, Z., Malwal, S. R., Liu, W., Shi, Y., Oldfield, E.*, Guo, R. T.*, Zhang, Y.* (2019). A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation. Immunity 50, 1043-1053. (IF=31.745)

2. Chen, C. C.#, Hu, X.#, Tang, X.#, Yang, Y.#, Ko, T. P., Gao, J., Zheng, Y., Huang, J. W., Yu, Z., Li, L., Han, S., Cai, N., Zhang, Y.*, Liu, W.*, Guo, R. T.* (2018). The Crystal Structure of a Class of Cyclases that Catalyze the Cope Rearrangement. Angewandte Chemie International Edition 57, 15060-15064.  (IF=15.336)

3. Malwal, S. R.#, Gao, J.#, Hu, X.#, Yang, Y.#, Liu, W., Huang J. W., Ko, T. P., Li, L., Chen, C. C., ODowd, B., Khade, R. L., Zhang, Y., Zhang, Y.*, Oldfield, E.*, Guo, R. T.* (2018). Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes. ACS Catalysis 8, 4299-4312. (IF=13.084)

4. Zeng, W.#, Li, X.#, Yang, Y.#, Min, J.#, Huang J. W., Liu, W., Niu, D., Yang, X., Han, X., Zhang, L., Dai, L., Chen, C. C.*, Guo, R. T.* (2022).Substrate-Binding Mode of a Thermophilic PET Hydrolase and Engineering the Enzyme to Enhance the Hydrolytic Efficacy. ACS Catalysis 12, 3033-3040. (IF=13.084)

5. Yang, Y.#, Ko, T. P.#, Chen, C. C.#, Huang, G., Zheng, Y., Liu, W., Wang, I., Ho, M., Hsu, S., O'Dowd, B., Huff, H., Huang, C. H., Docampo, R., Oldfield, E.*, Guo, R. T.* (2016). Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets. ACS Chemical Biology 11, 1362?1371.

6. Wang, J.#, Chen, C. C.#, Yang, Y.#, Liu, W., Ko, T. P., Shang, N., Hu, X., Xie, Y., Huang, J. W., Zhang, Y.*, Guo, R. T.* (2018). Structural Insight into a Novel Indole Prenyltransferase in Hapalindole-type Alkaloid Biosynthesis. Biochemical and Biophysical Research Communications 495, 1782-1788.

7. Xia, Y.#, Xie, Y.#, Yu, Z.#, Xiao, H., Jiang, G., Zhou, X., Yang, Y., Li, X., Zhao, M., Li, L., Zheng, M., Han, S., Zong, Z., Meng, X., Deng, H., Ye, H., Fa, Y., Wu, H., Oldfield, E., Hu, X., Liu, W.*, Shi, Y* and Zhang, Y.*. (2018). The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell 175, 1059-1073. (IF=38.637)

8. Tang, X.#, Xue, J.#, Yang, Y., Ko, T. P., Chen, C., Dai, L., Guo, R. T., Zhang, Y.* and Chen, C. C.*. (2019). Structural Insights into the Calcium Dependence of Stig Cyclases. RSC Advances 9, 13182-13185.

9. Gao, J.#, Ko, T. P.#, Chen, L.#, Malwal, S. R.#, Zhang, J., Hu, X., Qu, F., Liu, W., Huang, J. W., Cheng, Y. S., Chen, C. C., Yang, Y., Zhang, Y., Oldfield, E., and Guo, R. T.*. (2018). "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angewandte Chemie International Edition 57, 683-687. ( IF=12.959)

10. Zheng, Y.#, Ko, T. P.#, Yang, Y., Shao, W.*, Guo, R. T.*. (2015). Binding Mode of the Oxidized a-anomer of NAD+ to RSP, a Rex-family Repressor. Biochemical and Biophysical Research Communications 456, 733-736.

11. Zheng, Y., Chen, C. C., Ko, T. P., Xiao, X., Yang, Y., Huang, C. H., Qian, G., Shao, W.*, Guo, R. T.*. (2015). Crystal Structures of S-adenosylhomocysteine Hydrolase from the Thermophilic Bacterium Thermotoga Maritima. Journal of Structural Biology 190, 135-142.

12. Peng, W.#, Ko, T. P.#, Yang, Y., Zheng, Y., Chen, C. C., Zhen Zhu, Huang, C., Zeng, Y., Huang, J. W., Wang, Andrew H.-J., Liu, J.-R.*, and Guo, R. T.*. (2014). Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea. RSC Advances 9, 13182-13185.

六、获奖与荣誉称号

1. 2020年获得清华大学优秀博士毕业生

2. 2020年获清华大学优秀博士学位论文

3. 2020年获得启航奖

4. 2019年获得国家奖学金

5. 2019年获卓越奖学金

6. 2018年获光华奖学金

 

 

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