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教师名录

欧宝在线登录:张丽兰

作者:欧宝在线登录发布时间:2021年09月26日 10:09

 

一、基本信息

张丽兰,博士,副教授,硕士研究生导师

电子邮件:zhang_lilan(AT)163.com

研究方向:酶结构生物学

研究领域:结构生物学、酶结构及机理研究、酶定向改造

使用结构生物学手段对具有重要功能的蛋白质进行结构和机理研究,并基于结构进行理性设计和定向改造,主要包括:(1)萜类合成酶;(2)细胞色素P450酶;(3)工业酶。目前已在Nature Communications、Angew. Chem. Intl. Ed、JACSACS CatalysisSCI期刊发表论文14篇,其中3篇获选为封面文章。申请专利1项,2019年获天津市自然科学二等奖1项。

二、教育背景

2016.09–2019.07  中国科学院大学(中国科学院天津工业生物技术研究所),生物化学与分子生物学专业,博士,导师:郭瑞庭教授

2012.03–2014.03  中国科学院大学(中国科学院天津工业生物技术研究所),联合培养,硕士,导师:郭瑞庭教授

2011.09–2012.02  天津科技大学,轻工技术与工程(发酵)专业,硕士,导师:张娟琨教授

2007.09–2011.07  兰州理工大学,生物工程专业,本科,导师:张新国教授

三、工作经历

2021.10至今          欧宝在线登录,博士后,合作导师:郭瑞庭教授

2019.07–2021.09  欧宝在线登录,博士后,合作导师:郭瑞庭教授

2014.04–2016.08  中国科学院天津工业生物技术研究所,助理研究员。

四、主持或参加科研项目情况

1.    国家重大专项(青年项目),2021.01–2023.12,60万,项目骨干

2.    自然科学基金(青年基金)项目,2021.01–2023.12,24万,主持

3.    中国博士后特别资助(站中)项目,2020.07–2021.08,18万,主持

4.    中国博士后面上项目,2019.10–2021.08,8万,主持

5.    湖北省科技活动项目择优资助,2019.10–2021.08,2万,在研、主持

6.    国家重大专项,2019.12–2024.11,552万,参与

7.    湖北省创新群体,2020.03–2023.03,50万,参与

五、代表著作(#共同第一作者,*通讯作者)

1.       Chen CC, Han X, Li X, Jiang P, Niu D, Ma L, Liu W, Li S, Qu Y, Hu H, Min J, Yang Y, Zhang L, Zeng W, Huang JW*, Dai L*, Guo RT*. (2021) General features to enhance enzymatic activity of poly (ethylene terephthalate) hydrolysis. Nature Catalysis 4, 425–430. (IF 30471 Highlighted by ChemistryViews 科技日报 中国科学报)

2.     Chen CC, Min J, Zhang L, Yang Y, Yu X*, Guo RT*. (2021) Advanced understanding of the electron transfer pathway of cytochrome P450s. ChemBioChem 22, 1317–1328. (Review Cover story)

3.     Zhang L#, Xie Z#, Liu Z #, Zhou S, Ma L, Liu W, Huang JW, Ko T-P, Li X, Hu Y, Min J, Yu X, Guo RT*, Chen CC*. (2020) Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase Nature Communications 11, 2676 (IF 12.12 Highlighted by C&EN ChemistryViews 科技日报 中国科学报)

4.     Chen CC*, Zhang L, Yu X, Ma L, Ko T-P, Guo RT*. (2020) Versatile cis-isoprenyl diphosphate synthase superfamily members in catalyzing carbon-carbon bond formation. ACS Catalysis 10, 4717–4725. (IF 12.350 Review ACS Editors’ Choice Cover story)

5.     Chen CC#, Xue J #, Peng W # ,Wang B, Zhang L, Liu W, Ko T-P, Huang J W, Zhou S, Min J, Ma L, Dai L *, Guo R T*. (2020) Structural insights into thebaine synthase 2 catalysis. Biochemical and Biophysical Research Communications 529, 156–161.

6.     Huang JW, Niu D, Liu K, Wang Q, Ma L, Chen CC, Zhang L, Liu W, Zhou S, Min J, Wu S, Yang Y*, Guo RT*. (2020) Structure basis of non-structural protein pA151R from African Swine Fever Virus. Biochemical and Biophysical Research Communications 532, 108–113

7.     Zhang L #, Ko T-P #, Malwal SR #, Liu W, Zhou S, Oldfield E, Guo RT*, Chen CC*. (2019) Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism Biochemical and Biophysical Research Communications 511, 800–805.

8.     Yang Z #, Zhang L#, Yu X, Wu S, Yang Y, Hu Y, Li Q, Shang N, Guo RT, Chen CC, Dai L*, Liu W*. (2019) Crystal structure of TchmY from Actinoplanes teichomyceticus. Acta Crystallographica Section F: Structural Biology Communications 75, 570–575.

9.     Ma J #, Ko T-P # ,Yu X #, Zhang L, Ma L, Zhai C, Guo RT, Liu W, Li H, Chen CC*. (2019) Structural insights to heterodimeric cis-prenyltransferases through yeast dehydrodolichyl diphosphate synthase subunit Nus1. Biochemical and Biophysical Research Communications 515, 621–626.

10.  Chang Z#, Ansbacher T#, Zhang L#, Yang Y, Ko T-P, Zhang G, Liu W Huang JW, Dai L, Guo RT, Major DT*, Chen CC*. (2019) Crystal structure of LepI a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis. Organic Biomolecular Chemistry 17, 2070–2076. (Cover story)

11.  Zhang L#, Chen CC#, Ko T-P#, Huang JW, Zheng Y, Liu W, Wang I, Malwal SR, Feng X, Wang K, Huang CC, Hsu ST, Wang AH, Oldfield E*, Guo RT*. (2016) Moenomycin biosynthesis: structure and mechanism of action of the prenyl transferase MoeN5. Angewandte Chemie International Edition 2016 55, 4716–4720. (IF 12257)

12.  Chan HC#, Feng X#, Ko TP#, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Dean C, Liang PH ,Wang AH, Oldfield E*, Guo RT*. (2014) Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. Journal of the American Chemical Society 2014 136, 2892–2896. (IF 14.612)

13.  Lv P#, Zhang L#, Luo H#, Chen CC, Huang CH, Peng W, Wang K, Ko T-P, Zheng Y, Zhang J, Bin Y*, Guo RT*. (2014) Preliminary X-ray diffraction analysis of thermostable β-1 4-xylanase from Streptomyces sp S9. Acta Crystallographica Section F: Structural Biology Communications 70, 105–107.

14.  Zhang L#, Zhao P#, Chen CC#, Huang CH, Ko T-P, Zheng Y, Guo RT*. (2014) Preliminary X-ray diffraction analysis of a thermophilic β-1,3-1 4-glucanase from Clostridium thermocellum. Acta Crystallographica Section F: Structural Biology Communications 70, 946–948.

代表性封面文章

六、专利

1.    Chen, C. C., Huang, J. W., Dai, L. H., Yu, X. J., Chen, C. Y., Wu, S., Zhan, Z. C., Zhang, L. L., Zhai, C., Ma, L. X., Guo, R. T. Cellulase having improved enzymatic activity,授权号:US10479985B1,美国专利。

七、奖励与荣誉称号

2021年,湖北省省级人才项目获得者

2020 ,湖北省创新群体

2019 ,天津市自然科学二等奖

 

 

 

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