欧宝在线登录

教师名录

欧宝在线登录:贺妮莎

作者:欧宝在线登录发布时间:2021年04月28日 20:55

 

 

http://weblg.hubu.edu.cn:8080/_vsl/75060BEC31D2D6889CA331A4B65B2D39/AB082399/1C065

一、基本信息

贺妮莎,博士,副教授,硕士生导师,湖北省省级人才项目获得者

电子邮箱:nshe1992(AT)163.com

社会兼职:中国微生物学会会员、中国生物工程学会会员

研究领域:分子酶学(酶催化机制解析、酶分子改造)

二、教育背景

2008.092012.06  欧宝在线登录,获生物科学学士学位

2012.09–2018.01  中科院上海植物生理生态研究所,获微生物学博士学位,导师:肖友利研究员

三、工作经历

2019.03至今          欧宝在线登录生科院,副教授

2018.03–2020.03,College de France,博士后,合作导师:Marc Fontecave院士

四、科研项目

1.    湖北省教育厅中青年项目(202010701301003),2020.01–2021.12,多氧霉素生物合成途径中关键成环机制的研究,主持

2.    湖北省人才项目,2019.05–2024.05,主持

3.    国家自然科学基金面上项目(21572243),碳磷裂解酶参与的碳磷键断裂自由基反应机制研究,2016.01–2019.12,参与

4.    国家自然科学基金主任基金(21342013),PhnJ催化的有机膦化合物中碳磷键断裂的酶反应机制研究,2014.01–2014.12,参与

五、代表性论文#共同一作,*通讯作者)

1.      Li C, Jiang S, Du C, Lu Z, He N, Zhou Y, Zhang G*. (2021) High-level extracellular expression of a new β-N-Acetylglucosaminidase in Escherichia coli for producing GlcNAc. Frontiers in Microbiology 12, 478.

2.      Du C, Zhao X, Song W, He N, Jiang S, Zhou Y, Zhang G* (2021) Combined strategies to improve the expression of acidic mammalian chitinase in Pichia pastoris for the production of N, N'-diacetylchitobiose Biochemical Engineering Journal 167, 107907.

3.      Song, W, Zhang, N, Yang, M, Zhou, Y, He N*, Zhang G*. (2020) Multiple strategies to improve the yield of chitinase a from Bacillus licheniformis in Pichia pastoris to obtain plant growth enhancer and GlcNAc. Microbial Cell Factories 19, 1–11.

4.      Cheng Y, Xu J, Fu Y, He N*. (2020) Expression and regulation of pde6h by thyroid hormone during metamorphosis in Paralichthys olivaceus. Frontiers in Physiology 11, 244.

5.      Hu X, Yuan X, He N, Zhuang TZ, Wu P, Zhan, G*. (2019) Expression of Bacillus licheniformis α–amylase in Pichia pastoris without antibiotics-resistant gene and effects of glycosylation on the enzymic thermostability. 3 Biotech 9, 1–9.

6.      He N#, Wu P#, Lei Y, Xu B, Zhu X, Xu G, Chen W*, Xiao Y*. (2017) Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high–carbon sugar nucleoside antibiotics. Chemical science 8, 444–451.

7.      Qi X, Lin W, Ma M, Wang C, He Y, He N, Zhang P* (2016) Structural basis of rifampin inactivation by rifampin phosphotransferase. Proceedings of the National Academy of Sciences of the United States of America 113, 3803–3808.

欧宝在线登录-欧宝登录入口